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Australian Shepherd — Risk Profile | VetTools Clinical Intelligence

Australian Shepherd

DOG· MEDIUM· Lifespan: 12-15 years

🧬 Genetic Drug Sensitivities

Prevalence: Unknown

P-glycoprotein substrate. Reduced clearance in MDR1 mutants → neurotoxicity (ataxia, blindness, tremors, seizures, death).

AVOIDIvermectin→ Alternatives: Milbemycin Oxime, Selamectin (at labeled doses)

REDUCE DOSEAcepromazine

REDUCE DOSEButorphanol

MONITORCyclosporine

AVOIDTramadol

Condition	Prevalence	Onset	Severity	Screening
Hemangiosarcoma	Elevated	8-12 years	LIFE THREATENING	Abdominal ultrasound annually after age 7
MDR1 (ABCB1) Mutation	~50%	Birth	SEVERE	Genetic test (Embark, Wisdom Panel)
Hip Dysplasia	15-20%	1-2 years	MODERATE RISK	PennHIP or OFA radiographs by age 2
Epilepsy	~6%	1-5 years	MODERATE RISK	Monitor for seizure activity
Cataracts (HSF4)	15-20%	2-7 years	MODERATE RISK	CERF/OFA eye exam annually