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Dr. Rosie DVM/VetTools

Dashboard Drugs Interactions Dosage Breeds Toxicology Fluids Emergency Patient

Clinical Intelligence

Dashboard Drugs Interactions Dosage Breeds Toxicology Fluids Emergency Patient

Clinical decision support tool. Does not replace professional veterinary judgment. Always verify recommendations with current references.

Collie (Rough/Smooth) — Risk Profile | VetTools Clinical Intelligence

Breeds›Collie (Rough/Smooth)

Collie (Rough/Smooth)

DOG· LARGE· Lifespan: 12-14 years

🧬 Genetic Drug Sensitivities

🔴 MDR1 (nt230(del4))

Prevalence: Unknown

P-glycoprotein substrate. Reduced clearance in MDR1 mutants → neurotoxicity (ataxia, blindness, tremors, seizures, death).

AVOIDIvermectin→ Alternatives: Milbemycin Oxime, Selamectin (at labeled doses)

REDUCE DOSEAcepromazine

REDUCE DOSEButorphanol

MONITORCyclosporine

AVOIDTramadol