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Dalmatian — Risk Profile | VetTools Clinical Intelligence

Dalmatian

DOG· LARGE· Lifespan: 11-13 years

🧬 Genetic Drug Sensitivities

Prevalence: Unknown

Azathioprine metabolized to 6-mercaptopurine → uric acid. Dalmatians already have 10-20x normal uric acid levels. Increased urate stone risk.

MONITORAzathioprine→ Alternatives: Mycophenolate, Cyclosporine

Condition	Prevalence	Onset	Severity	Screening
Hyperuricosuria (Urate Urolithiasis)	~100% (genetic)	1-4 years	MODERATE RISK	Urinalysis for urate crystals. Low-purine diet mandatory.
Deafness (Congenital Sensorineural)	15-30% unilateral or bilateral	Birth	MODERATE RISK	BAER test at 5-8 weeks

Test	Breed Normal	General Range	Note
Uric Acid (Serum)	2-4 mg/dL (cannot lower further)	0.2-0.8 mg/dL	All Dalmatians have SLC2A9 mutation. Uric acid is 10-20x normal. Low-purine diet and adequate hydration mandatory. Consider allopurinol if recurrent stones.
Uric Acid (Urine)	200-600 mg/day	10-60 mg/day	Dalmatians excrete uric acid instead of allantoin. Monitor for urate crystals on urinalysis.