Clinical decision support tool. Does not replace professional veterinary judgment. Always verify recommendations with current references.
Dalmatian
DOG· LARGE· Lifespan: 11-13 years
Thinking about this breed for your home? Read the owner suitability guide
🧬 Genetic Drug Sensitivities
🔴 SLC2A9 (Hyperuricosuria mutation)
Prevalence: Unknown
Azathioprine metabolized to 6-mercaptopurine → uric acid. Dalmatians already have 10-20x normal uric acid levels. Increased urate stone risk.
MONITORAzathioprine→ Alternatives: Mycophenolate, Cyclosporine
📋 Breed Predispositions
| Condition | Prevalence | Onset | Severity | Screening |
|---|---|---|---|---|
| Hyperuricosuria (Urate Urolithiasis) | ~100% (genetic) | 1-4 years | MODERATE RISK | Urinalysis for urate crystals. Low-purine diet mandatory. |
| Deafness (Congenital Sensorineural) | 15-30% unilateral or bilateral | Birth | MODERATE RISK | BAER test at 5-8 weeks |
🩸 Breed-Specific Lab Normals
| Test | Breed Normal | General Range | Note |
|---|---|---|---|
| Uric Acid (Serum) | 2-4 mg/dL (cannot lower further) | 0.2-0.8 mg/dL | All Dalmatians have SLC2A9 mutation. Uric acid is 10-20x normal. Low-purine diet and adequate hydration mandatory. Consider allopurinol if recurrent stones. |
| Uric Acid (Urine) | 200-600 mg/day | 10-60 mg/day | Dalmatians excrete uric acid instead of allantoin. Monitor for urate crystals on urinalysis. |