Dr. Rosie DVM

Clinical decision support tool. Does not replace professional veterinary judgment. Always verify recommendations with current references.

Greyhound — Risk Profile | VetTools Clinical Intelligence

Greyhound

DOG· LARGE· Lifespan: 10-14 years

🧬 Genetic Drug Sensitivities

🔴 CYP2B11 (Reduced hepatic metabolism)

Prevalence: Unknown

Sighthounds have low body fat and reduced CYP2B11 activity. Propofol redistribution is slower → prolonged recovery. Reduce induction dose by 25-50%.

REDUCE DOSEPropofol

REDUCE DOSEKetamine

REDUCE DOSEAcepromazine

📋 Breed Predispositions

Condition	Prevalence	Onset	Severity	Screening
Greyhound-specific lab normals	100%	Birth	MILD	Use breed-specific reference ranges

🩸 Breed-Specific Lab Normals

Test	Breed Normal	General Range	Note
Platelet Count	100,000-200,000/μL	175,000-500,000/μL	Greyhounds have physiologically lower platelets. Do not treat as thrombocytopenia.
Total T4	0.5-1.5 μg/dL	1.0-4.0 μg/dL	Greyhounds have physiologically lower T4. Do not diagnose hypothyroidism on T4 alone.
Creatinine	1.6-2.4 mg/dL	0.5-1.5 mg/dL	Higher creatinine due to greater muscle mass. Not indicative of renal disease.
PCV/Hematocrit	55-65%	37-55%	Higher PCV is physiologic in Greyhounds. Do not phlebotomize.

🏥 Anesthesia Considerations

⚠ Sighthound Anesthetic Sensitivity

Low body fat → prolonged recovery from lipid-soluble agents (thiopental, propofol). Reduce induction doses 25-50%. Use lean-body-mass dosing. CYP2B11 deficiency in Greyhounds = slow barbiturate/propofol metabolism. Prefer alfaxalone for induction. Extended post-anesthetic monitoring required.