Clinical decision support tool. Does not replace professional veterinary judgment. Always verify recommendations with current references.
German Shepherd
DOG· LARGE· Lifespan: 9-13 years
Thinking about this breed for your home? Read the owner suitability guide
🧬 Genetic Drug Sensitivities
🔴 MDR1 (nt230(del4))
Prevalence: Unknown
P-glycoprotein substrate. Prolonged sedation in MDR1 dogs. Reduce dose by 25-50%.
REDUCE DOSEAcepromazine
REDUCE DOSEButorphanol
MONITORCyclosporine
AVOIDTramadol
AVOIDIvermectin→ Alternatives: Milbemycin Oxime, Selamectin (at labeled doses)